Born on October 31, 1843, when Louisa was 15 she married William Otis Colson on February 6, 1859 in Newnansville, Alachua County, Florida. They lived at a place called Jennings Lake, in Gilchrist County, Florida, and had the following children:
i. Claude William (1860-1924)
ii. Martha Mina (1866-1957)
iii. Lemuel Wilson (1869-1953)
iv. Solomon Warren (1872-1939)
v. Mike (1875-1942)
Louisa died in Trenton, Gilchrist, Florida on August 5, 1881 and was buried in Pine Grove Cemetery, Levy County, Florida ; she was 37.